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Does Testosterone Replacement Therapy (TRT) Result in Loss of Hair?

Does Testosterone Replacement Therapy (TRT) Result in Loss of Hair?
Apr 17,2022

Androgen, particularly testosterone, regulates hair growth in men. Androgenic alopecia, also called male pattern baldness, affects about 80% of males. This condition has symptoms such as thinning, recession, and hair loss, usually from the scalp's vertex and temporal zones.

Men with androgenic alopecia are genetically predisposed to hair loss from the effect of DHT (dihydrotestosterone). DHT is similar to testosterone but is more active. DHT acts on the bulb of the hair follicles, causing thinning and loss of hair. Unlike the hair on the temporal zones and vertex of the scalp, the hair on the side of the scalp is resistant to androgens.

DHT occurs from testosterone breakdown by an enzyme called 5-alpha-reductase. Men who are likely to have androgenic alopecia may have increased hair loss due to testosterone replacement therapy (THT) which increases the amount of DHT circulating in the body.

Testosterone replacement therapy may not result in hair loss for men who aren't genetically predisposed to male pattern baldness. Some hairs are resistant to the effect of testosterone or DHT, so some men go bald, and others don't.

Clinical studies show that men who undergo testosterone (TRT) and are at risk of androgenic alopecia experience hair loss more often following the initial year of TRT. Hair loss in the first year of TRT is low eve for men with existing male pattern baldness.

Other studies have found that the duration of taking testosterone supplements may affect hair loss, as long exposure to exogenous testosterone increases the risk of male pattern baldness. Whether injection, pellet, or gel, the type of testosterone used has no significant difference in hair loss.

Although men on TRT may experience an increased rate of male pattern baldness, using testosterone can increase body and facial hair growth.

Men undergoing TRT and showing hair loss can use Finasteride (Propecia) as testosterone treatment hair loss to slow down or eliminate the risk of androgenic alopecia.

How does Finasteride (Proscar, Propecia) prevent hair loss?

Finasteride inhibits the action of 5-alpha reductase. This is the generic name of Propecia and Proscar. Finasteride prevents hair loss in men at risk of male pattern baldness by reducing DHT circulation in the body. Less circulating DHT prevents hair recession, loss, and regression.

What makes Dutasteride (Avodart) different from Finasteride (Propecia, Proscar)?

Several differences between Dutasteride and Finasteride are available. Finasteride is a competitive inhibitor of type-2,5alpha-reductase isoform found in the scalp and prostate. Dutasteride inhibits type-2 and type 1,5alpha-reductase, common in the skin and liver. Its half-life is 35 days, unlike Finasteride, with a half-life of 0.3 days. This makes Dutasteride more effective in reducing DHT levels in 20 – 24 weeks.

Dutasteride circulates longer in the body and reduces prostate size and urinary symptoms. Finasteride and Dutasteride have the same sexual side effects.

Are there sexual side effect of finasteride (Propecia, Proscar) and dutasteride (Avodart)?

Finasteride and Dutasteride can have sexual side effects such as impaired erections and ejaculatory functions. The rate of erectile dysfunction in men taking Finasteride is about 5 – 9%. A study found side effects in 15% of men taking Finasteride after a year of treatment. The side effect of taking a lower dose of Finasteride is lower than in men taking a higher dose of the medication for treating an enlarged prostate.

Finasteride's possible side effects include erectile dysfunction, loss of sex drive, and decreased ejaculatory volume.

How does Propecia differ from Proscar?

Propecia and Proscar contain the same active ingredient – Finasteride. However, they have different dosages of the active ingredient. Propecia approved dosage for male pattern baldness is 1mg of Finasteride, while the approved dosage for Proscar is 5mg for men with lower urinary tract symptoms and enlarged prostate.

Is Finasteride or Dutasteride better for hair loss prevention?

A study of random people taking these testosterone therapy hair loss showed that Dutasteride had higher efficacy than Finasteride in improving new hair growth and reducing thin hair count in men with male pattern baldness.

What is the right dosage for Finasteride in treating male pattern baldness?

A milligram of Finasteride, commonly called Propecia, is sufficient for treating male pattern baldness.

Can I take Finasteride (Propecia) without eating or after eating?

You can take Finasteride (Propecia) without eating or after eating. Food doesn't affect the absorption of Propecia. Most men take Propecia in the morning.

Another option to consider is undergoing hair transplant surgery for male pattern baldness. You can contact Turkey Hair Transplants on 020 7371 9175 to book a consultation for hair transplant surgery.